Co-infection is a phenomena by which a host or cell is infected by at least two pathogens (1, 2). The severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, has resulted in the death of greater than 200,000 people in the United States in less than one year, with an impending influenza season, raising the prospect of co-infection-related complications (3, 4, 5). We mined a published microarray dataset (6) to discover genes associated with viral co-infection in the blood of human patients, including co-infections involving human rhinovirus, enterovirus, respiratory syncytial virus A, human coronavirus HKU1 and influenza B. We found significant differential expression of heterogenous nuclear ribonucleoproteins including hnRNP K in the blood of patients with viral co-infections. These data suggest hnRNPs may be of relevance to immunity against viral co-infections or utilized by viruses during completion of the viral life cycle in the context of co-infection.