Background: We report presumably the first known case of a high-risk COVID-19 positive patient with co-morbidities including Diabetes Mellitus (DM), Hypertension (HTN), Hypothyroidism and Chronic Kidney Disease (CKD), treated successfully using an Integrative Therapy plan based on Ayurveda and Yoga. Recently, some evidence has been emerging on the use of Ayurveda for treatment of COVID-19. The classical texts of Ayurvedic medicine such as Charaka Samhita and Sushruta Samhita contain the description of pandemics of similar proportions and describe them as Janapadoddhvansa meaning the destruction of communities, along with their causes and treatment. Case Presentation: The reported case, a 55 year old male confirmed (tested) patient of COVID-19, who first took modern western medicine (MWM) for 7 days before seeking the Integrative Therapy. The patient has comorbidities including DM, HTN, Hypothyroidism and CKD and had developed symptoms including fever (which was resolved by the time Integrative Therapy was started), sore throat, dry cough, body ache, weakness, bad taste and smell, and heaviness in abdomen. Based on the patient's symptoms and co-morbidities, a treatment plan including Ayurvedic medicines, Yoga protocol, dietary recommendations and lifestyle modifications was prescribed by a registered Ayurveda doctor and a Yoga consultant. The patient started experiencing improvement in all the symptoms within 2 days after starting the treatment; he reported approximately 75% relief from the symptoms after 5 days, and almost complete relief within 9 days. Also, the blood sugar levels (both Fasting Blood Sugar FBS, and Post Prandial Blood Sugar PPBS) exhibited significant improvement after 5 days, and came inside the normal range within 12 days. The patient was diagnosed free from infection on the basis of RT-PCR test on the 21st day (sample taken on the 19th day). Conclusions: The Integrative Therapy was found effective in curing the COVID-19 patient with above-mentioned co-morbidities. Moreover, a significant improvement in blood sugar levels (not under control with modern medicine) was also achieved. Integrative Therapy based on classical texts of Ayurveda and Yoga may offer a promising and scalable treatment option for COVID-19 patients. A suitably designed randomized controlled trial is needed to assess its efficacy.