TET2 is differentially expressed in coronavirus infections.

The novel coronavirus SARS-CoV-2 has infected nearly 20,000,000 in less than one year (1, 2). We mined published and public data (3-8) to discover the most significant transcriptional changes induced in host cells and tissues following coronavirus infections. We identified the ten eleven (TET) methylcytosine dioxygenase TET2 as a differentially expressed gene following infection of human cells with the Middle East Respiratory Syndrome (MERS) coronavirus, Human Coronavirus 229, and in the lungs of mice infected with the Severe Acute Respiratory Syndrome (SARS) coronavirus SARS-CoV-1. TET2 may be a relevant target of study for understanding coronavirus pathogenesis.
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