Cross-sectional, internet-based surveys were conducted to assess the impact of the COVID-19 pandemic on daily stress for older adults living with HIV in Palm Springs, CA (N=100). Participants’ mean age was 64.2, most were non-Hispanic white (88.0%), men (96.0%) and identified as gay or lesbian (93.0%). Respondents reported high compliance with physical distancing (96.0%) and mask wearing (98.0%). One-third of respondents experienced financial challenges. A quarter (24.0%) skipped a dose of their HIV medication during COVID-19 and many experienced disruptions to their healthcare (46.0%). Decreases in the quality of relationships with friends was reported by 40.7% of respondents. DSM criteria for PTSD was met by 22.0%. Younger (ages 51-63) respondents were significantly more likely to report financial challenges, miss HIV medication doses, and have higher PTSD severity scores. In an adjusted logistic regression, higher PTSD severity scores and disruption to healthcare were associated with missing doses (p’s <.05).