The goal of this note is to better understand determinants that can explain the willingness to vaccinate against COVID-19. For this purpose, we conduct a survey in Germany in which we ask ourselves whether this “time is different” from the willingness to be vaccinated against infection by influenza viruses. Our sample does not only comprise students with and without healthcare background, we also analyze a notable amount of healthcare professionals. We find that healthcare professionals exhibit a considerably greater willingness to vaccinate against flu than healthcare and non-healthcare students. In contrast, the willingness to vaccinate against COVID-19 is quite similar among the populations. In both contexts, COVID-19 and flu, trust (e.g. media, activities of the government) seems to play a central role in the decision whether to vaccinate or not.